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Volume 20, Issue 1 (Winter & Spring 2023)
ASJ 2023, 20(1): 15-22 |
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Almasi Ghale S, Gholami M, Bazgir B, Abednatanzi H. Training Can Potentially Accelerate Cardiac Output and Inhibit Cardiomyocyte Autophagy in Old Male Rats. ASJ 2023; 20 (1) :15-22
URL: http://anatomyjournal.ir/article-1-613-en.html
URL: http://anatomyjournal.ir/article-1-613-en.html
1- Department of Exercise Physiology, Faculty of Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2- Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3- Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2- Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3- Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Abstract: (377 Views)
Introduction: Aging affects cardiac function and heart output. Regular exercise can improve heart function in old age. This experimental study evaluated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiomyocyte autophagy and cardiac function.
Methods: In this study, 24 older male Wistar rats (>20 months) were divided into three groups of Control, HIIT, and MICT. The animals in the control group received no training, while the HIIT and MICT groups performed high and moderate training intensities at different intervals. Aerobic power and training capacity (VO2max) were also assessed before the training. After eight weeks of training (5 days/week), two-dimensional echocardiography was used for the sonographic assessment of the heart, and the tissue samples of the left ventricle were dissected for assessing gene expression (PGC-1α and FOXO-3α). Data were analyzed using SPSS software, version 19 and presented using Mean±SD. P<0.05 was considered as statistically significant.
Results: The expression of the PGC-1α gene significantly increased, while the FOXO-3α gene expression significantly decreased in the HIIT and MICT groups compared to the control animals (p<0.05). Left ventricle end-systolic dimension decreased (p<0.05), while the left ventricular end-diastolic diameter, ejection fraction, and fractional shortening increased (p<0.05) in the training groups compared to the control animals. These changes were also significant in the HIIT group compared to the MICT group (p<0.05)
Conclusion: HIIT can reduce the expression of autophagy genes and improve cardiac function in aged heart more than MICT.
Methods: In this study, 24 older male Wistar rats (>20 months) were divided into three groups of Control, HIIT, and MICT. The animals in the control group received no training, while the HIIT and MICT groups performed high and moderate training intensities at different intervals. Aerobic power and training capacity (VO2max) were also assessed before the training. After eight weeks of training (5 days/week), two-dimensional echocardiography was used for the sonographic assessment of the heart, and the tissue samples of the left ventricle were dissected for assessing gene expression (PGC-1α and FOXO-3α). Data were analyzed using SPSS software, version 19 and presented using Mean±SD. P<0.05 was considered as statistically significant.
Results: The expression of the PGC-1α gene significantly increased, while the FOXO-3α gene expression significantly decreased in the HIIT and MICT groups compared to the control animals (p<0.05). Left ventricle end-systolic dimension decreased (p<0.05), while the left ventricular end-diastolic diameter, ejection fraction, and fractional shortening increased (p<0.05) in the training groups compared to the control animals. These changes were also significant in the HIIT group compared to the MICT group (p<0.05)
Conclusion: HIIT can reduce the expression of autophagy genes and improve cardiac function in aged heart more than MICT.
Keywords: High-intensity interval training (HIIT), Moderate-intensity continuous training (MICT), Autophagy, FOXO3-3α, PGC-1α, Aged heart
Type of Study: Original |
Subject:
Gross Anatomy
Received: 2021/12/23 | Accepted: 2022/04/30 | Published: 2023/01/1
Received: 2021/12/23 | Accepted: 2022/04/30 | Published: 2023/01/1
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