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Volume 3, Issue 3 (Autumn 2005)
ASJ 2005, 3(3): 203-211 |
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Roshan del D, Kalavi M, Ghaffari S, Gharavi M, Roshan Del G R, Gol Ali Poor M J. Morphometric Changes of Rat Testis After Subchronic Oal Lead Intoxication and D-Penicillamine Treatment. ASJ 2005; 3 (3) :203-211
URL: http://anatomyjournal.ir/article-1-419-en.html
URL: http://anatomyjournal.ir/article-1-419-en.html
Danial Roshan del 
1, Margan Kalavi , Soraya Ghaffari , Mohammad Gharavi , Gholam Reza Roshan Del , Mohammad Jafar Gol Ali Poor
1, Margan Kalavi , Soraya Ghaffari , Mohammad Gharavi , Gholam Reza Roshan Del , Mohammad Jafar Gol Ali Poor
1- Anatomy & Histology Department, Gorgan Medical Faculty, Gorgan, Iran.
Abstract: (711 Views)
Purpose: The aim of this study was to assess the efficacy of D-Penicillamine in reducing lead induced morphometric changes in rat testis.
Materials and Methods: Male adult rats were exposed to 0.4% lead acetate in drinking water for 8 weeks. After this period, 6 rats sacrificed and testes were removed to evaluate the effects of lead intoxication. The remained lead exposed rats were divided into two groups: one group received distilled water and the other group received 25-35 mg/kg/day of oral D-p treatment for six weeks, after one week of recovery. Testis morphometric changes were studied in H&E stained sections.
Results: Width of germinal epithelium and number of sertoli cells were decreased after 8 weeks of lead intoxication (P<0.05). These parameters were still significantly lower than control group after both of recovery and treatment periods (P<0.05).
Conclusion: This study showed that subchronic oral lead intoxication induces some changes in adult testis which are not reversible even after D-P administration.
Materials and Methods: Male adult rats were exposed to 0.4% lead acetate in drinking water for 8 weeks. After this period, 6 rats sacrificed and testes were removed to evaluate the effects of lead intoxication. The remained lead exposed rats were divided into two groups: one group received distilled water and the other group received 25-35 mg/kg/day of oral D-p treatment for six weeks, after one week of recovery. Testis morphometric changes were studied in H&E stained sections.
Results: Width of germinal epithelium and number of sertoli cells were decreased after 8 weeks of lead intoxication (P<0.05). These parameters were still significantly lower than control group after both of recovery and treatment periods (P<0.05).
Conclusion: This study showed that subchronic oral lead intoxication induces some changes in adult testis which are not reversible even after D-P administration.
Type of Study: Original |
Subject:
Morphometry
Received: 2021/12/26 | Accepted: 2005/10/18 | Published: 2005/10/18
Received: 2021/12/26 | Accepted: 2005/10/18 | Published: 2005/10/18
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