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ASJ 2023, 20(1): 0-0 |
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Taheri A, Bazgir B, Abednatanzi H, Gholami M. The Effects of High-Intensity Interval and Moderate-Intensity Continuous Trainings on Autophagy, Cardiac Remodeling and Heart Function in Aged Male Rats. ASJ 2023; 20 (1)
URL: http://anatomyjournal.ir/article-1-611-en.html
URL: http://anatomyjournal.ir/article-1-611-en.html
1- Phd Candidate of Exercise Physiology, Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989917600144. Mail: azadetaheri1992@gmail.com. ORCID: 0000-0002-3609-3996.
2- Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Phone: +989334781110. Mail: Bazgirbehzad@yahoo.com & Bazgirbehzad@bmsu.ac.ir. ORCID:0000-0002-5128-7617.
3- Assistant Professor, Department of Professional Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989126107064. Mail: abednazari@gmail.com & h-abednatanzy@srbiau.ac.ir. ORCID: 0000-0001-6638-1131.
4- Associate professor, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989121491868. Mail: Gholami_man@yahoo.com.
2- Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Phone: +989334781110. Mail: Bazgirbehzad@yahoo.com & Bazgirbehzad@bmsu.ac.ir. ORCID:0000-0002-5128-7617.
3- Assistant Professor, Department of Professional Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989126107064. Mail: abednazari@gmail.com & h-abednatanzy@srbiau.ac.ir. ORCID: 0000-0001-6638-1131.
4- Associate professor, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Phone: +989121491868. Mail: Gholami_man@yahoo.com.
Abstract: (223 Views)
Introduction: Aging is a physiological process affecting the heart function. Training is known as a factor accelerating the heart output specially in aged individuals. In the present experimental study, the authors aimed to assess the role of High-intensity interval training (HIIT) and Moderate-intensity continuous training (MICT) on autophagy, cardiac remodeling and cardiac function.
Methods: 24 aged (≈20 months) male Wistar rats were divided into 3 groups of Control, HIIT and MICT. The special trainings of high-intensity interval and Moderate-intensity continuous were for 8 weeks. Aerobic power and training capacity were also assessed. 2 dimensional echocardiography was also applied for assessment of cardiac indices. At the end of the experiment, tissue sampling of cardiac tissue was applied and gene expression was assessed using qRT-PCR technique. Data were analyzed using SPSS (v.19) software.
Results: After HIIT and MICT trainings, no significant changes were detected regarding the animal weight. Also, mTORC1, Atg16, and Atg7 gene expression and EF and FS were accelerated in HIIT and MICT groups than control animals. Besides, COLIII gene expression, LVEDD, and LVESD were increased significantly (p<0.05) in HIIT and MICT animals than control.
Conclusion: Training can potentially improve the cardiac output in elderly. Besides, the HIIT seems effective than MICT.
Methods: 24 aged (≈20 months) male Wistar rats were divided into 3 groups of Control, HIIT and MICT. The special trainings of high-intensity interval and Moderate-intensity continuous were for 8 weeks. Aerobic power and training capacity were also assessed. 2 dimensional echocardiography was also applied for assessment of cardiac indices. At the end of the experiment, tissue sampling of cardiac tissue was applied and gene expression was assessed using qRT-PCR technique. Data were analyzed using SPSS (v.19) software.
Results: After HIIT and MICT trainings, no significant changes were detected regarding the animal weight. Also, mTORC1, Atg16, and Atg7 gene expression and EF and FS were accelerated in HIIT and MICT groups than control animals. Besides, COLIII gene expression, LVEDD, and LVESD were increased significantly (p<0.05) in HIIT and MICT animals than control.
Conclusion: Training can potentially improve the cardiac output in elderly. Besides, the HIIT seems effective than MICT.
Keywords: Aging, cardiac output, echocardiography, High-intensity interval training, Moderate-intensity continuous training, mTORC1, Atg16, Atg7, COLIII, LVEDD, LVESD, EF, FS
Type of Study: Original |
Subject:
Gross Anatomy
Received: 2023/11/3 | Accepted: 2024/04/20 | Published: 2024/01/20
Received: 2023/11/3 | Accepted: 2024/04/20 | Published: 2024/01/20
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