Volume 19, Issue 1 (Winter & Spring- In Press 2022)                   ASJ 2022, 19(1): 0-0 | Back to browse issues page

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Zohreh-Vand F, Mazdeh M, Tapak L, Kamaledin Hadei S, Bahiraei M. Morphometrical Evaluation of Corpus Callosum Using Mid-Sagittal Brain MRI Images in Patients With Relapsing-Remitting Multiple Sclerosis Referred to Besat Hospital in Hamadan from April 2011 To April 2021; A Retrospective Study. ASJ. 2022; 19 (1)
URL: http://anatomyjournal.ir/article-1-575-en.html
1- Member of Research Committee, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Biostatistics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran.
4- Department of Radiology, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran.
5- Department of Radiology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:   (348 Views)
Introduction: Corpus callosum (CC) as an intracranial organ is located in midline of cerebrum communicating both right and left hemispheres. CC undergoes morphological changes in multiple sclerosis (MS). Since the morphometrical changes of organs are directly associated with geographical regions, thus the aim of this study was to investigate the morphological alteration of CC in patients with relapsing-remitting MS in Hamadan (Iran) in a retrospective study from April 2011 to April 2021.
Materials and Methods: Following conduction of inclusion and exclusion criteria, respectively 54 and 128 Brain MRI images of RRMS patients and healthy individuals were examined morphologically using PmsDICOMViewer software. Two main morphological indices of area (mm2) and longitudinal (mm) parameters were examined in midsagittal sections of Brain MRI images, including the area of CC (ACC) and associated segments, length of CC (LCC) and height of CC (HCC). Finally, the data were analysed by SPSS software (v. 19). P<0.05 was considered as significancy level and data were presented as mean±SEM.
Results: Following MS onset, total area of CC (ACC) was decreased significantly (p<0.05) in MS patients than control. Also, the area of rosterum/genu (ARG) and area of anterior half midbody of CC (AAMB) showed significant (p<0.05) incremental and decrimental trends, respectively. In other indices, no significant (p>0.05) differences were detected.
Conclusion: Morphometrical measurements of CC are associated with the presence of MS. By the assessment of the anterior half of CC in brain MRI images (ARG and AAMB), the diagnosis of MS can be occurred. Thus, the results of investigation can be proposed as criteria for radiological confirmation of MS diseaese.

Type of Study: Original | Subject: Morphometry
Received: 2022/04/19 | Accepted: 2022/05/10 | Published: 2022/02/26

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