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Volume 3, Issue 3 (Autumn 2005)
ASJ 2005, 3(3): 163-171 |
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Sadeghi Y, Piryaee A, Almasi Tork S, Roozbehi A. Ultrastructural Study of Cadmium Effects on Photoreceptors and Ganglionic Cells of Retinal Layer in Mice Embryo. ASJ 2005; 3 (3) :163-171
URL: http://anatomyjournal.ir/article-1-416-en.html
URL: http://anatomyjournal.ir/article-1-416-en.html
1- Department, Shahid Beheshti Medical Science University, Tehran, Iran.
Abstract: (785 Views)
Purpose: In this study, TEM was used to asses the ultra structural effects of Cd on Photoreceptor and Ganglionic cells of mouce retinal layer.
Materials and Methods: 30 mice hi1Vebeen used in three groups (experimental I, II & control). On 9th day of gestation, experimental groups have received a single IP injection of Cadmium- chlorid (Cd C12) solution in saline, 3 mg/kg and 5 mg/kg respectively and control group received only distilled water. The mice were euthanized on day 15 of gestation. Specimens for TEM were prepared.
Results: External fragment shortness of photoreceptors, apoptotic nuclei, heterochromatic nuclei, deletion of nucleous membrane, invisible nucleolus, and mitochondrial changes in apoptotic cells were observed in experimental groups.
Conclusion: Cadmium exposure causes apoptotic changes in Photoreceptors and Ganglionic cells.
Materials and Methods: 30 mice hi1Vebeen used in three groups (experimental I, II & control). On 9th day of gestation, experimental groups have received a single IP injection of Cadmium- chlorid (Cd C12) solution in saline, 3 mg/kg and 5 mg/kg respectively and control group received only distilled water. The mice were euthanized on day 15 of gestation. Specimens for TEM were prepared.
Results: External fragment shortness of photoreceptors, apoptotic nuclei, heterochromatic nuclei, deletion of nucleous membrane, invisible nucleolus, and mitochondrial changes in apoptotic cells were observed in experimental groups.
Conclusion: Cadmium exposure causes apoptotic changes in Photoreceptors and Ganglionic cells.
Type of Study: Original |
Subject:
Morphometry
Received: 2021/12/26 | Accepted: 2005/10/18 | Published: 2005/10/18
Received: 2021/12/26 | Accepted: 2005/10/18 | Published: 2005/10/18
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