Volume 6, Issue 25 And 26 (Winter & Spring 2008)                   ASJ 2008, 6(25 And 26): 591-626 | Back to browse issues page

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Pirouz M, Valadbeigy T, Shahverdi A H, Baharvand H. In Vitro Production of Germ Cells from Stem Cells: Hypes and Hopes. ASJ 2008; 6 (25 and 26) :591-626
URL: http://anatomyjournal.ir/article-1-558-en.html
In Vitro Production of Germ Cells from Stem Cells: Hypes and Hopes
Mahdi Pirouz , Tahereh Valadbeigy , Abdol Hossein Shahverdi , Hossein Baharvand1
Abstract:   (1016 Views)
Several lines of evidence have reported that mouse ESCs can successfully differentiate into primordial germ cells (PGC) as well as into mature male and female gametes. Human ESCs and adult stem cells (ASCs) can also differentiate into PGCs. Differentiation of ESCs into germ cells of various stages seems to be a spontaneous and quick process, probably due to the nature of ESCs themselves and the microenvironment of the culture conditions that favor this process. Although the functionality of these ESC-derived gametes remains to be established, derivation of both male and female gametes from ESCs raises the possibility of using these gametes to gain a better understanding of basic reproductive biology and, in particular, in conjunction with nuclear transfer technology, to extend the potential for therapeutic cloning and the treatment or infertility. 
Keywords: Stem Cells, Germ Cells, Sperm, Oocyte
Full-Text [PDF 1193 kb]   (397 Downloads)    
Type of Study: Original | Subject: Morphometry
Received: 2022/01/3 | Accepted: 2008/02/14 | Published: 2008/02/14
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