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Volume 7, Issue 28 And 29 (Autumn & Winter 2009)
ASJ 2009, 7(28 And 29): 145-152 |
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Khalatbari A R, Altiraihi T, Beygi Boroujeni M, Ahmadvand H, Tavafi M, Tamjidipour A. Study of Neuroprotective Effects of Green Tea Antioxidant on Spinal Cord Injury of Rat. ASJ 2009; 7 (28 and 29) :145-152
URL: http://anatomyjournal.ir/article-1-497-en.html
URL: http://anatomyjournal.ir/article-1-497-en.html
Ali Reza Khalatbari 
1, Taghi Altiraihi , Mandana Beygi Boroujeni , Hassan Ahmadvand , Majid Tavafi , Ahmad Tamjidipour
1, Taghi Altiraihi , Mandana Beygi Boroujeni , Hassan Ahmadvand , Majid Tavafi , Ahmad Tamjidipour
Abstract: (737 Views)
Purpose: Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury (SCI) has not yet been studied.Materials and Methods: Rats were randomly divided into three groups of 18 rats each as follows: sham group (laminectomy), control group (SCI) and experimental group (EGCG). Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment.Results: The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group.Conclusion: EGCG treatment decreased secondary spinal cord injury.
Type of Study: Original |
Subject:
Morphometry
Received: 2021/12/27 | Accepted: 2009/11/28 | Published: 2009/11/28
Received: 2021/12/27 | Accepted: 2009/11/28 | Published: 2009/11/28
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