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Volume 4, Issue 3 (Autumn 2006)
ASJ 2006, 4(3): 225-239 |
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Mahdi Zadeh M, Arian Poor R, Joughataei M T, Roughani M, Noubakht M, Asgari H R. The Study of Quercetin Effects on Behavioral and Nigrostriatal Tissue in the Experimental Model of Parkinson in Adult Rat. ASJ 2006; 4 (3) :225-239
URL: http://anatomyjournal.ir/article-1-448-en.html
URL: http://anatomyjournal.ir/article-1-448-en.html
Mahdi Mahdi Zadeh1 
, Roya Arian Poor , Mohammad Taghi Joughataei , Mehrdad Roughani , Maliheh Noubakht , Hamid Reza Asgari
, Roya Arian Poor , Mohammad Taghi Joughataei , Mehrdad Roughani , Maliheh Noubakht , Hamid Reza Asgari
1- Anatomy Departmen, Iran University Of Medical Sciences, Tehran, Iran.
Abstract: (910 Views)
Purpose: The aim of this study is investigating the effect of quercetin on behavioral and nigrostriatal tissue in the experimental model of Parkinson in adult rat.
Materials and Methods: In this study we used 80 male rats from Wistar spring with body weight of 200-250 g. In order to make parkinson model, 6-OHDA (12.5 mg/kg) was injected intrastriatal unilaterally using stereotaxic method. Lesion rats were pretreated intraperitoneally with quercetin (20 mg/kg) one hour before surgery and once a day with 10 & 20 mg/kg doses up to one month after surgery. Rotational behaviore of apomorphine-induced postlesion was measured during the fifth week after surgery considered as treatment efficiency indicator. SNC cells were studied with nissle staning method.
Results: Behavioral tests in the fifth week revealed that Apomorphine caused evident contralateral rotation in lesion group (P<0.001) and very low rotation in treatment group (P<0.01) comparing with sham group. Treatment group showed decrease in numbers of rotation (P<0.01) comparing with lesion group. Treatment groups with 10 and 20 mg/kg Quercetin did not show significant differences statistically. The number of SNC neurons in left side showed significant reduction in lesion group (P<0.001) and treatment groups (P<0.01) comparing with right side, but did not show significant changes in sham group.
Conclusion: Behavioral and structural results indicated short-term intra-peritoneal administration of quercetin is effective as an antioxidant in treatment of early PD and may enhance the survival of nigral dopaminergic neurons.
Materials and Methods: In this study we used 80 male rats from Wistar spring with body weight of 200-250 g. In order to make parkinson model, 6-OHDA (12.5 mg/kg) was injected intrastriatal unilaterally using stereotaxic method. Lesion rats were pretreated intraperitoneally with quercetin (20 mg/kg) one hour before surgery and once a day with 10 & 20 mg/kg doses up to one month after surgery. Rotational behaviore of apomorphine-induced postlesion was measured during the fifth week after surgery considered as treatment efficiency indicator. SNC cells were studied with nissle staning method.
Results: Behavioral tests in the fifth week revealed that Apomorphine caused evident contralateral rotation in lesion group (P<0.001) and very low rotation in treatment group (P<0.01) comparing with sham group. Treatment group showed decrease in numbers of rotation (P<0.01) comparing with lesion group. Treatment groups with 10 and 20 mg/kg Quercetin did not show significant differences statistically. The number of SNC neurons in left side showed significant reduction in lesion group (P<0.001) and treatment groups (P<0.01) comparing with right side, but did not show significant changes in sham group.
Conclusion: Behavioral and structural results indicated short-term intra-peritoneal administration of quercetin is effective as an antioxidant in treatment of early PD and may enhance the survival of nigral dopaminergic neurons.
Type of Study: Original |
Subject:
Morphometry
Received: 2021/12/26 | Accepted: 2006/10/18 | Published: 2006/10/18
Received: 2021/12/26 | Accepted: 2006/10/18 | Published: 2006/10/18
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