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Showing 3 results for Tabatabaei

Mansoureh Soleimani, Mahdi Mahdi Zadeh, Masoomeh Bakhshayesh, Sara Soleimani, Parvaneh Tabatabaei,
Volume 5, Issue 18 (Spring 2007)
Abstract

Purpose: So far there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied effects of The Mitochondrial K-ATP channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat.
Materials and Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Neurological assessment was conducted after 24h reperfusion by consciousness scoring and motor function according to the methods reported by Lemay and Tarloe. After tissue processing and crysel violet staining total and normal cell number was assessed in parietal cortex.Data was analyzed by ANOVA software.
Results: The normal cell count of neuronal population significantly increased in the K-ATP channel opener (Diazoxide) treated ischemia-reperfusion group compared with the control group. Cell count and neurological function scores were dependent to dose of K-ATP channel regulators in vivo.
Conclusions: Our results showed that Diazoxide treatment leads to better preservation of cortical neurons in rat.
Masome Rashno, Seyed Reza Fatemi Tabatabaei, Mahmood Khaksary Mahabady, Shahab Ghaderi,
Volume 11, Issue 1 (Winter 2014)
Abstract

Introduction: - Significant increase in usage of silver nanoparticles (AgNPs) in consumer products, has increased its exposures to human and animals. Although there are some reports regarding the effects of AgNPs on complex organisms, no report was found as to its effects on neurobehavioral ontogeny. 
Methods: To investigate the effects of maternal exposure to AgNPs on development of neurobehavioral reflexes as well as physical indexes of growthand development during preweaning period, virgin female NMRI mice were treated with zero, 5 and 50 μg/mouse AgNPs. AgNPs were injected subcutaneously (S.C) to female mice, immediately following male exposure and at once every three days until parturition. Reproductive performance of dams were assessed and home cage activity and developmental landmarks of all pups were observed daily. Gross necropsy was performed on the 28th day. 
Results: No significant differences were observed in dams' and pups' weight. Survival rate was decreased (p<0.05) in NP5 group and a clear hyperactivity was observed in NP50 group. Prenatal exposure to AgNPs delayed the development of the some pups' neurobehavioral reflexes which were supposed to take place during the first four days following birth. The weight of spleen was decreased in AgNPs treated mice and the weight of liver was increased in male offspring who was exposed to AgNPs before birth. 
Conclusion: This study revealed that prenatal exposure to AgNPs delayed neurobehavioral development during the early stages of the pre-weaning period. Furthermore, more attention should be paid to alteration of lymphoid organ and liver weights of offspring.

Seyed Mohammad Hadi Mirab, Mohammad Barbarestani, Seyyed Mohammad Tabatabaei, Soodeh Shahsavari, Mohammad Bagher Minaeii Zangi,
Volume 15, Issue 1 (Winter & Spring 2018)
Abstract

Introduction: Disc degeneration is a natural aging process characterized by changes in appearance and chemical structure of the disc. This degeneration leads to back pain. In regard to the limitation of current therapeutical methods for patients with degenerated discs, arthroplasty has been suggested as an alternative method. To manufacture artificial discs for Iranians, determining normal lumbar intervertebral disc dimensions is necessary. Thus, we measure the most important dimensions of normal lumbar intervertebral discs in Iranians using Magnetic Resonance Imaging (MRI).
Methods: we studied lumbar intervertebral discs of 34 people who were 40-60 years old in Medical Imaging Center of Imam Khomeini Hospital. Out of them, 14 people without herniated disc and any other abnormalities related to spinal column on MRI were selected. There were 7 males and 7 females, and their average age was 48.07 years (range: 40 to 59 years). For accurate measurements, the relevant disc distances were measured by two radiologists and then the mean value for each segment was calculated.
Results: The mean (SD) values of anterior intervertebral disc height for L1/L2 to L5/S1 levels were measured and found as follows: 10.82(1.59) mm, 13.09(1.21) mm, 15.21(1.24) mm, 18.14(1.49) mm, 18.71(1.61) mm. The mean (SD) values of middle intervertebral disc height for L1/L2 to L5/S1 levels were measured as follows: 10(1.89) mm, 11.59(1.51) mm, 12.45(1.79) mm, 13.82(1.96) mm, 12.99(2.53) mm. The mean (SD) values of posterior intervertebral disc height for L1/L2 to L5/S1 levels were found as follows: 7.31(1.71) mm, 8.58(1.66) mm, 9.08(1.22) mm, 10.14(1.01) mm, 8.51(1.08) mm. The mean (SD) values of anterior-posterior disc length for L1/L2 to L5/S1 levels were found as follows: 30.23(2.71) mm, 32.03(2.43) mm, 32.86(2.44) mm, 33.08(2.37) mm, 31.33(2.55) mm. The mean (SD) values of transversal disc length for L1/L2 to L5/S1 levels were found as follows: 48.24(2.23) mm, 51.27(1.92) mm, 52.59(1.69) mm, 55.12(1.69) mm, 52.87(2.14) mm.
Conclusion: Knowledge of the normal lumbar intervertebral disc dimensions in every society is useful for surgical reconstruction to treat lumbar spine diseases and for medical manufacturers to make proper surgical devices in this regard.



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