Mesenchymal Stem Cells: History, Isolation and Biology

Baghban Eslami Nezhad, Mohammad Reza

Volume 5, Issue 18 (Spring 2007) ASJ 2007, 5(18): 61-73 | Back to browse issues page

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Baghban Eslami Nezhad M R. Mesenchymal Stem Cells: History, Isolation and Biology. ASJ 2007; 5 (18) :61-73
URL: http://anatomyjournal.ir/article-1-465-en.html

Mesenchymal Stem Cells: History, Isolation and Biology

Mohammad Reza Baghban Eslami Nezhad

Stem Cell Department, Royan Institute, Tehran, Iran.

Abstract: (647 Views)

Mesenchymal stem cells (MSCs) as a kind of adult stem cells possess two properties of long term selfrenewal ability and multilineage differentiation potential into skeletal cell lineages. MSCs were first isolated and described from bone marrow samples. Further investigations have identified several other tissues as alternative sources for these cells. In spite of the clinical importance of MSCs, some biological aspects of them including their self-renewal proliferation and differentiation potential have not yet been fully understood. Furthermore, the specific surface markers for these cells remained to be investigated. In present paper, the existing data regarding to the different aspects of mesenchymal stem cells including the history, isolation method, surface markers, in vitro culture and expansion of the cells, self-renewal proliferation and finally their differentiation potential have been reviewed.

Keywords: Stem cells, Biology, History

Full-Text [PDF 324 kb] (334 Downloads)

Type of Study: Original | Subject: Morphometry
Received: 2021/12/26 | Accepted: 2007/04/1 | Published: 2007/04/1

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