An unusual origin of the common interosseous artery is reported in the paper. During educational dissection of a 37-year-old male, a rare variation in the origin of common interosseous artery of the right upper limb was observed. The common interosseous artery directly separated from radial artery. The right anterior interosseous artery is continued from common interosseous artery. Anterior and posterior ulnar recurrent arteries arising from common interosseous artery were noted on the right side of upper limb. In the present case, the median artery was replaced with anterior interosseous artery. Additionally, the ulnar artery passed superficially on flexor digitorum superficialis. In the cadaver, there was no other arterial or muscular variation. The embryological interpretation of this variation may be attributed to arising of the artery as a result of modifications to the normal pattern of capillary vessel maintenance and regression. Regarding the above mentioned variations, practical medical experiences are necessary to identify the variations of arterial pattern of upper limb vessels.