Introduction: To examine the effects of opium dependence and cigarette smoking on semen
quality and sperm parameters, the semen quality of men who abuse opiates and/or smoke
cigarettes was investigated in a retrospective study.
Methods: Male partners of 1325 infertile couples attending the infertility clinic for intrauterine
insemination (IUI) procedure were divided into non-smoking non-opium (NS/NO), smoking
and non-opium (S/NO), non-smoking and opium (NS/O), smoking and opium (S/O), and opium
dependence regardless of smoking status (O/RS) groups. Two samples were collected from each
subject and were analyzed in accordance to WHO criteria.
Results: Subjects in different groups were comparable regarding mean age, duration of
abstinence, and familial history of infertility, whereas duration of infertility was longer in all
groups than in NS/NO group (P<0.05). The volume of semen, liquefaction time and pH differed
significantly between S/NO and NS/NO groups (P<0.05). In addition, more men in S/NO group
were diagnosed to be teratozoospermic than other groups (P=0.018). Sperm progression was
significantly lower in NS/O than in NS/NO group (P<0.05).
Conclusion: These findings suggest that opium dependence and cigarette smoking alter semen
and sperm production and quality differently.
Type of Study:
Original |
Received: 2014/03/11 | Accepted: 2014/07/9 | Published: 2014/11/1