Introduction: Endometriosis is a prevalent gynecological disorder among women which is
diagnosed by the growth of endometrial tissue outside of uterus and is mainly accompanied
by severe pelvic pain and infertility. P53 also known as cellular tumor antigen P53 inside
codons 11, 72 and 248 are contained with single nucleotide changes in which tends to be nearly
rampant.This will probably be increasing the chances of endometriosis infection to some great
extent.
Our aim was to evaluate the connection between endometriosis and polymorphism inside the
codons 11, 72 and 248 of P53 gene.
Methods: In this study, single nucleotide changes in codons 11, 72 and 284 of TP53 gene
among 44 persons infected with endometriosis and the same studying population for noninfected
group have been examined. After primer design and amplification of polymorphic
sequences by PCR, the polymorphisms of related codons have been evaluated by the digestion
method (RFLP).
Results: In this study on the codon 72, there were seen differences in the distribution of genotype
frequencies of normal polymorphic subjects and control subjects with endometriosis. At codons
11 and 248, there were observed no significant correlations between polymorphic and normal
genotypes of endometriosis and non-endometriosis groups.
Conclusion: According to the results, we can say that probably polymorphism
Type of Study:
Original |
Received: 2013/07/19 | Accepted: 2013/12/18 | Published: 2014/02/1