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Volume 11, Issue 1 (Winter 2014)
ASJ 2014, 11(1): 25-32 |
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Sabbaghziarani F, Rasapour S, Mortezaee K, Oryan S, Sharifzadeh M, Khanavi M et al . Could Melissa Officinalis Extract Restore Streptozotocin-Induced Spatial Memory Impairment in Rats?. ASJ 2014; 11 (1) :25-32
URL: http://anatomyjournal.ir/article-1-63-en.html
URL: http://anatomyjournal.ir/article-1-63-en.html
Fatemeh Sabbaghziarani1 
, Sharareh Rasapour2 , Keywan Mortezaee1 , Shahrbano Oryan2 , Mohammad Sharifzadeh1 , Mahnaz Khanavi1 , Gholamreza Hassanzadeh 1
, Sharareh Rasapour2 , Keywan Mortezaee1 , Shahrbano Oryan2 , Mohammad Sharifzadeh1 , Mahnaz Khanavi1 , Gholamreza Hassanzadeh 1
1- Tehran University of Medical Sciences
2- Khwarizmi University
2- Khwarizmi University
Abstract: (7110 Views)
Introduction: Alzheimer disease is a progressive and irreversible neuropsychiatric disorder.
Melissa Officinalis improves anxiety and clinical dementia symptoms caused by AD therefore,
the purpose of the present study was to evaluate the effect of Mellisa extract on spatial memory
deficit induced by STZ in MWM examination of male wistar rats.
Methods: In the present study, 112 male wistar rats (220-270g) were used. Spatial learning
deficit was induced by bilateral ICV injection of STZ (3mg/kg) via cannula then, the Melissa
extract in different doses administrated by gavage and Morris Water Maze for measurement of
spatial learning parameters was performed.
Results: The results of this study demonstrated that gavage of the 200mg/kg of Melissa
officinalis in combination with STZ, followed by significant reduction in two parameters: Time
and Distance.
Conclusion: Totally, the data indicate possible therapeutic value of M. officinalis extract on
spatial learning improvement.
Type of Study: Original |
Received: 2013/04/21 | Accepted: 2013/09/29 | Published: 2014/02/1
Received: 2013/04/21 | Accepted: 2013/09/29 | Published: 2014/02/1
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