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Purpose: The goal of this research was to study of the protective effects horse tail (HT) plant extract on the central degeneration of alpha motoneurons (AM) of spinal cord.Materials and Methods: The lesioned sciatic rats were divided into sham, control and 3 experimental groups and treated by 15 mg/kg, ip HT extract. The animals were care for one month and then were sacrificed and perfused cardially by 10% formaldehyde and the lumbar segments of their spinal cord dissected and sampled. After histological processing, by using a stereological technique (dissector), the numerical density (Nv) of AM in the ventral horn of lumbar spinal cord were estimated in all groups. Results: The results are showing that although the Nv of AM of shams is significantly lower than the control (p<0.001), but the Nv of AM of almost of all experimental groups is higher than of sham group (p<0.05). More over there is no significant difference between experimental and control groups.Conclusion: These findings indicate that administration of HT extract has a beneficial effect on the survival of AM and may prevent or delay the central degeneration.

Keywords: Horsetail Plant, Alphamotoneurons, Central Degeneration, Rat

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