Volume 1, Issue 1 (Winter 2003)                   ASJ 2003, 1(1): 17-23 | Back to browse issues page

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Mehdizadeh M, Rastegar T, Noubakht M, Joghataei M T, Parivar K. Effect of Mercuric Chloride on Development of the Spinal Cord of Rat Embroys. ASJ. 2003; 1 (1) :17-23
URL: http://anatomyjournal.ir/article-1-303-en.html
1- Anatomy Department, Iran Medical Sciences University, Tehran, Iran.
Abstract:   (345 Views)
Introduction: Mercuric chloride (HgC12) is a white, poison and cristalin powder which is absorbed through GI and skin, and excreted from kidney. It is used in compound of contrast material and in beauty creams and laxative drugs. Chronic poisoning with mercuric chloride causes sensorial, mobile, behavioral and mental disorders.
To study the effect of mercuric chloride on the growth of the embryos.
Materials & Methods: 42 rats from Sprague Dawley after seeing vaginal plague that is zero day of gestation were divided into seven groups: one intact group, three control groups that received normal saline solution and three experimental groups that injected mercuric chloride 2mg/kg/Ip in eighth, ninth and tenth days of gestation. Then, embryos were removed from uterus in 15th day and were studied by light microscope.
Results: Microscopic study of spinal cord showed that cell death mitosis division, and extracellular space were increased and cell accumulation was decreased. Diameter of ventricular zone has been increased and diameter of mantle and marginal zones, internal and external diameter of spinal cord have been reduced.
Conclution: The Present study showed that mercuric chloride as an apoptogenesis caused cell death and loss of neuroblasts that caused develoJ1ment of neural tube disorders. Therefore it has theratogenic effects during gestation period.
     
Type of Study: Original | Subject: Morphometry
Received: 2021/11/16 | Accepted: 2003/02/21 | Published: 2003/02/21

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