Volume 13, Issue 2 (Spring 2016 -- 2016)                   ASJ 2016, 13(2): 117-124 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abdolmaleki A, Mastery Farahani R, Ghoreishi S K, Shaerzadeh F, Aliaghaei A, Mirjavadi S H et al . Magnetic Resonance Imaging-Based Morphometric Assessment of Sexual Dimorphism of Corpus Callosum. ASJ. 2016; 13 (2) :117-124
URL: http://anatomyjournal.ir/article-1-175-en.html
1- Department of Anatomy and Cell Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Statistics, Faculty of Sciences, University of Qom, Qom, Iran.
3- Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
4- Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5- Hearing Disorders Research Center, Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (3275 Views)

Introduction: Interhemispheric transmission of signal is done by corpus callosum (CC) as the largest fiber tract in brain. CC comprised 5 segments of rostrum, genu, body, isthmus, and splenium. Contradictory reports exist about sexual dimorphism of CC. We designed this study to assess probable sexual differences of CC and its different parts in men and women.
Methods: We analyzed magnetic resonance (MR) images of 68 females and 60 males in midsagittal view by PmsDViewer software. Data were analyzed by Student t test. These cases had no neurologic and pathologic diseases.
Results: MRI anthropometric analysis indicates that all segments of CC are larger in men compared to women. Moreover, our results also revealed that although all segments of CC were bigger in men, this increase in size was more prominent in the anterior segments of CC.
Conclusion: These findings indicate gender-related differences regarding CC segments. Notably, brain size as an interfering variable was eliminated in this study.

Full-Text [PDF 746 kb]   (1311 Downloads)    
Type of Study: Review |
Received: 2015/10/29 | Accepted: 2016/02/19 | Published: 2016/05/1

References
1. Allen JS, Damasio H, Grabowski TJ, Bruss J, Zhang W. Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum. Neuroimage. 2003; 18(4):880-94. doi: 10.1016/s1053-8119(03)00034-x [DOI:10.1016/S1053-8119(03)00034-X]
2. Allen LS, Richey MF, Chai YM, Gorski RA. Sex differences in the corpus callosum of the living human being. Journal of Neuroscience. 1991; 11(4):933-42. doi: 10.1016/s0149-7634(96)00049-8 [DOI:10.1016/S0149-7634(96)00049-8]
3. Bishop KM, Wahlsten D. Sex differences in the human corpus callosum: myth or reality? Neuroscience & Biobehavioral Reviews. 1997; 21(5):581-601. doi: 10.1016/s0149-7634(96)00049-8 [DOI:10.1016/S0149-7634(96)00049-8]
4. Clarke JM, Zaidel E. Anatomical-behavioral relationships: corpus callosum morphometry and hemispheric specialization. Behavioural brain research. 1994; 64(1-2):185-202. doi: 10.1016/0166-4328(94)90131-7 [DOI:10.1016/0166-4328(94)90131-7]
5. Constant D, Ruther H. Sexual dimorphism in the human corpus callosum? A comparison of methodologies. Brain research. 1996; 727(1):99-106. doi: 10.1016/0006-8993(96)00358-7 [DOI:10.1016/0006-8993(96)00358-7]
6. Davatzikos C, Resnick SM. Sex differences in anatomic measures of interhemispheric connectivity: correlations with cognition in women but not men. Cerebral Cortex. 1998; 8(7):635-40. doi: 10.1093/cercor/8.7.635 [DOI:10.1093/cercor/8.7.635]
7. DeLacoste-Utamsing C, Holloway RL. Sexual dimorphism in the human corpus callosum. Science. 1982; 216(4553):1431-432. doi: 10.1126/science.7089533 [DOI:10.1126/science.7089533]
8. Driesen NR, Raz N. The influence of sex, age, and handedness on corpus callosum morphology: A meta-analysis. Psychobiology. 1995; 23(3):240-47. doi: 10.1371/journal.pone.0000792 [DOI:10.1371/journal.pone.0000792]
9. Frazier TW, Hardan AY. A meta-analysis of the corpus callosum in autism. Biological Psychiatry. 2009; 66(10):935-41. doi: 10.1016/j.biopsych.2009.07.022 [DOI:10.1016/j.biopsych.2009.07.022]
10. Giedd JN, Rumsey JM, Castellanos FX, Rajapakse JC, Kaysen D, Vaituzis AC, et al. A quantitative MRI study of the corpus callosum in children and adolescents. Developmental Brain Research. 1996; 91(2):274-80. doi: 10.1016/0165-3806(95)00193-x [DOI:10.1016/0165-3806(95)00193-X]
11. McCullough ME, Bellah CG, Kilpatrick SD, Johnson JL. Vengefulness: Relationships with forgiveness, rumination, well-being, and the Big Five. Personality and Social Psychology Bulletin. 2001; 27(5):601-10. doi: 10.1177/0146167201275008 [DOI:10.1177/0146167201275008]
12. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS, Faraone SV, Tsuang MT. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cerebral Cortex. 2001; 11(6):490-97. doi: 10.1093/cercor/11.6.490 [DOI:10.1093/cercor/11.6.490]
13. Gupta T, Singh B, Kapoor K, Gupta M, Kochhar S. Age and sex related variations in corpus callosal morphology. Nepal Medical College Journal. 2008; 10(4):215. doi: 10.1111/j.1447-073x.2008.00227.x [DOI:10.1111/j.1447-073X.2008.00227.x]
14. Holloway RL, Anderson PJ, Defendini R, Harper C. Sexual dimorphism of the human corpus callosum from three independent samples: relative size of the corpus callosum. American Journal of Physical Anthropology. 1993; 92(4):481-98. doi: 10.1002/ajpa.1330920407 [DOI:10.1002/ajpa.1330920407]
15. Holloway RL, De Lacoste MC. Sexual dimorphism in the human corpus callosum: an extension and replication study. Human Neurobiology. 1986; 5(2):87-91. doi: 10.1126/science.7089533 [DOI:10.1126/science.7089533]
16. Huster RJ, Westerhausen R, Herrmann CS. Sex differences in cognitive control are associated with midcingulate and callosal morphology. Brain Structure and Function. 2011; 215(3-4):225-35. doi: 10.1007/s00429-010-0289-2 [DOI:10.1007/s00429-010-0289-2]
17. Johnson SC, Farnworth T, Pinkston JB, Bigler ED, Blatter DD. Corpus callosum surface area across the human adult life span: effect of age and gender. Brain Research Bulletin. 1994; 35(4):373-77. doi: 10.1016/0361-9230(94)90116-3 [DOI:10.1016/0361-9230(94)90116-3]
18. Karaismailoğlu S, Erdem A. The effects of prenatal sex steroid hormones on sexual differentiation of the brain. Journal of the Turkish German Gynecological Association. 2013; 14(3):163. doi: 10.5152/jtgga.2013.86836 [DOI:10.5152/jtgga.2013.86836]
19. Kertesz A, Polk M, Black SE, Howell J. Sex, handedness, and the morphometry of cerebral asymmetries on magnetic resonance imaging. Brain Research. 1990; 530(1):40-48. doi: 10.1016/0006-8993(90)90655-u [DOI:10.1016/0006-8993(90)90655-U]
20. Leonard CM, Towler S, Welcome S, Halderman LK, Otto R, Eckert MA, et al. Size matters: cerebral volume influences sex differences in neuroanatomy. Cerebral Cortex. 2008; 18(12):2920-931. doi 10.1093/cercor/bhn052 [DOI:10.1093/cercor/bhn052]
21. Luders E, Rex DE, Narr KL, Woods RP, Jancke L, Thompson PM, Mazziotta JC, Toga AW. Relationships between sulcal asymmetries and corpus callosum size: gender and handedness effects. Cerebral Cortex. 2003; 13(10):1084-93. doi: 10.1093/cercor/13.10.1084 [DOI:10.1093/cercor/13.10.1084]
22. Nottebohm F, Arnold AP. Sexual dimorphism in vocal control areas of the songbird brain. Science. 1976; 194(4261):211-13. doi 10.1126/science.959852 [DOI:10.1126/science.959852]
23. Salat D, Ward A, Kaye JA, Janowsky JS. Sex differences in the corpus callosum with aging. Neurobiology of Aging. 1997; 18(2):191-97. doi: 10.1016/s0197-4580(97)00014-6 [DOI:10.1016/S0197-4580(97)00014-6]
24. Sullivan EV, Rosenbloom MJ, Desmond JE, Pfefferbaum A. Sex differences in corpus callosum size: relationship to age and intracranial size. Neurobiology of Aging. 2001; 22(4):603-11. doi: 10.1016/s0197-4580(01)00232-9 [DOI:10.1016/S0197-4580(01)00232-9]
25. Takeda S, Hirashima Y, Ikeda H, Yamamoto H, Sugino M, Endo S. Determination of indices of the corpus callosum associated with normal aging in Japanese individuals. Neuroradiology. 2003; 45(8):513-18. doi: 10.1007/s00234-003-1019-8 [DOI:10.1007/s00234-003-1019-8]
26. Tomasch J. Size, distribution, and number of fibres in the human corpus callosum. The Anatomical Record. 1954; 119(1):119-35. doi: 10.1002/ar.1091190109 [DOI:10.1002/ar.1091190109]
27. Weis S, Weber G, Wenger E, Kimbacher M. The controversy about a sexual dimorphism of the human corpus callosum. International Journal of Neuroscience. 1989; 47(1-2):169-73. doi: 10.3109/00207458908987430 [DOI:10.3109/00207458908987430]
28. Welcome SE, Chiarello C, Towler S, Halderman LK, Otto R, Leonard CM. Behavioral correlates of corpus callosum size: Anatomical/behavioral relationships vary across sex/handedness groups. Neuropsychologia. 2009; 47(12):2427-435. doi: 10.1016/j.neuropsychologia.2009.04.008 [DOI:10.1016/j.neuropsychologia.2009.04.008]
29. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain. 1989; 112(3):799-835. doi: 10.1093/brain/112.3.799 [DOI:10.1093/brain/112.3.799]

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


Designed & Developed by : Yektaweb