Volume 12, Issue 4 (Autumn 2015 -- 2015)                   ASJ 2015, 12(4): 183-190 | Back to browse issues page

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Pourmollaabbassi B, Hashemibeni B, Esfandiari E. A Review Study: Effect of Growth Factors on Human Mesenchymal Stem Cells Differentiation into Cartilage Tissue. ASJ. 2015; 12 (4) :183-190
URL: http://anatomyjournal.ir/article-1-129-en.html
1- Student of Tissue engineering Department of Tissue Engineering, School of Basic Engineering, Islamic Azad University of Najafabad, Isfahan, Iran.
2- PhD Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Ph.D Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:   (2375 Views)

Hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. After some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. Currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. In this regard, tissue regeneration has found mesenchymal stem cells (MSCs) with self-renewal and multipotential abilities as the best candidates for this process. Growth and differentiation of MSCs are induced by growth factors. The purpose of this review article is to evaluate the effect of growth factors and their signaling pathways involved in differentiation of mesenchymal stem cells into chondrocytes in vitro conditions.

Full-Text [PDF 476 kb]   (1216 Downloads)    
Type of Study: Editorial |
Received: 2015/06/17 | Accepted: 2015/08/9 | Published: 2015/11/1

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