Volume 17, Issue 2 (Summer & Autumn- Issue in Progress 2020)                   ASJ 2020, 17(2): 6-6 | Back to browse issues page

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Dalvand H, Hematfar A, Behpour N. The Interactive Effect of Curcumin Supplementation and Short-Term Swimming Exercise on the Expression of PDGF-BB and TGF-β1 Genes in Alcoholic Male Rats. ASJ. 2020; 17 (2) :6-6
URL: http://anatomyjournal.ir/article-1-247-en.html
1- Department of Exercise Physiology, Boroujerd Branch, Islamic Azad University, Boroujerd, Iran.
2- Department of Exercise Physiology, Boroujerd Branch, Islamic Azad University,Boroujerd, Iran.
3- Faculty of Physical Education, Razi University, Kermanshah, Iran.
Abstract:   (35 Views)
Background: Applying curcumin and sports exercises were suggested for the treatment of hepatic disorders. The present study aimed to investigate the effect of two-weeks of exhaustive swimming and curcumin supplementation on the expression of Platelet-Derived Growth Factor (PDGF-BB) and Transforming Growth Factor Beta 1 (TGF-β1) genes resulting from alcohol consumption in Wistar male rats.
Methods: In total, 32 heads of Wistar male rats were randomly selected from pharmacology college, Tehran University. Accordingly, they were divided into 4 equal groups of control, exercise, supplement, and supplement-exercise. Firstly, every 8 hours within 4 days, the alcohol gavage was attempted in all groups according to the bodyweight of each rat. Then, the renunciation period started. Subsequently, the exercise period, including long-term swim into the water initiated for two groups of exercise and supplement-exercise. To treat the supplement and supplement-exercise groups, curcumin was used. Eventually, ratschr('39') body was dissected after anesthetizing, and to study the expression of PDGF-BB and TGF-β1 genes, the real-time PCR technique was used.
Results: The curcumin supplementation demonstrated a significant reduction in the expression of the genes PDGF-BB (P=0.025) and TGF-β1 (P=0.033). Furthermore, in the exercise group, a significant decrease was observed in the expression of the genes PDGF-BB (P=0.007) and TGF-β1 (P=0.001). The interaction of exercise and supplement also significantly reduced the expression level of the genes PDGF-BB (P=0.040) and TGF-β1 (P=0.013).
Conclusion: The expression reduction of PDGF-BB and TGF-β1 genes in this research suggested that exercise and curcumin consumption could protect hepatic tissue against hurt. This protection is achieved through controlling HSC activation and prevent the adverse effect of alcohol on the liver.
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Type of Study: Original | Subject: Developmental Anatomy
Received: 2019/05/26 | Accepted: 2019/09/7 | Published: 2020/07/11

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