en Original Original <b> Introduction: </b>Cyclophosphamide is a chemotherapy drug with several side effects on various organs such as male reproductive system that can cause infertility. In this study, we assessed combined effect of ginger and pumpkin extractson rat testis after CP injection. <div><b>Methods: </b>Forty adult male rats were randomly divided into 4 groups: The control group received intraperitoneal injection of isotonic saline solution. The cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg_1BW) intraperitoneally. Combined extracts (ginger+ pumpkin) group received orally 300 mg combined extracts and combined extracts(ginger+ pumpkin) +CP groups received orally 300 mg combined extracts for a period of 6 weeks after CP injection. <div><b>Results: </b>Our results showed that although ginger extract could not change testis weight, testosterone, malondialdehyde (MDA) and ROS, antioxidant level in serum was increased significantly. Epithelium thickness and tube diameter were decreased in combined groups with or without CP in comparison to control group. The combined extract could improve histological changes in both combined extract and combined extract+ CP compared to CP group, which could be attributed to the higher serum level of antioxidants. </div><div><b>Conclusion:</b> The administration of combined extracts </div></div> Testis, Ginger, Pumpkin, Cyclophosphamide, Biochemical parameters 33 40 http://anatomyjournal.ir/browse.php?a_code=A-10-65-1&slc_lang=en&sid=1 Forouzan Mohamadi forouzan.mohamadi@gmail.com 1003194753284600419 1003194753284600419 No Kashan University of Medical Sciences Hossein Nikzad nikzad_h@kaums.ac.ir 1003194753284600420 1003194753284600420 Yes Kashan University of Medical Sciences Aliakbar Taherian Aliakbar Taherian 1003194753284600421 1003194753284600421 No Kashan University of Medical Sciences Mohsen Taghizadeh mohsenta44@yahoo.com 1003194753284600422 1003194753284600422 No Kashan University of Medical Sciences Abolfazl Azami-Tameh aazami@kaums.ac.ir 1003194753284600423 1003194753284600423 No Kashan University of Medical Sciences Homayon Naderian naderian_h@kaums.ac.ir 1003194753284600424 1003194753284600424 No Kashan University of Medical Sciences Mohammad Ali Atlasi atlasi-m@kaums.ac.ir 1003194753284600425 1003194753284600425 No Kashan University of Medical Sciences