Anatomical Sciences Journal
مجله علوم تشریح
ASJ
Basic Sciences
http://anatomyjournal.ir
1
admin
17286158
17286158
en
jalali
1385
5
1
gregorian
2006
8
1
4
2
online
1
fulltext
fa
Study of Genes Expression Involved in Apoptosis (Bax, Survivin) After Induced Cold Injury on Sensorimotor Cortex of Mouse Brain and Treatment With Magnesium Chloride
Morphometry
Morphometry
Original
Original
<strong>Purpose</strong>: The purpose of this study was to investigate the expression of Bax and surviving after cold injury and the ability of magnesium chloride to inhibit of apoptosis.<br>
<strong>Materials and Methods</strong>: To produce cold injury, a metal probe cooled with liquid nitrogen was applied to the surface of the mouse intact skull above the parietal lobe by force of 100 gr for 30 sec. Brains were removed 72 h after cold injury and sections were prepared to study immunohistochemistry reactions of Bax and Survivin antibodies. The data were analyzed using t- tests.<br>
<strong>Results</strong>: The results indicated that expression of Bax was higher in model group comparing with treated ones. Survivin was expressed more in the treated group and there was significant difference with model group (p<0.05).<br>
<strong>Conclusion</strong>: MgCL2 with optimum dose causes activate expression of Survivin and inhibition of apoptosis.
Brain injury, Cold injury, Mgcl2, Apoptosis, Bax, Survivin
175
184
http://anatomyjournal.ir/browse.php?a_code=A-10-304-136&slc_lang=fa&sid=1
Maryam
Nam Avari
10031947532846006348
10031947532846006348
No
Mansoureh
Movahedin
10031947532846006349
10031947532846006349
Yes
Anatomy Department, Tarbiat Modares University, Tehran, Iran.
Taghi
Altarihi
10031947532846006350
10031947532846006350
No