fa Morphometry Morphometry Original Original <strong>Purpose</strong>: This study was carried out to isolate mesenchymal stem cells from full-term cord blood and to differentiate these cells into osteoblastic cells.<br> <strong>Materials and Methods</strong>: It this study, mesenchymal stem cells were isolated from cord blood and expanded by being cultured in the flask several times. First, the cord blood monoeuc1earcells were separated by ficoll - Hypac before they were cultured in culture media; the medium was exchanged every week Next, the adherent cells were collected and expanded. The cord- blood mesenchymal stem cells were differentiated into osteoblastic cells by dexamethasone, ascorbic acid and b-glycerol phosphate.<br> <strong>Results</strong>: The expanded cells were similar to fibroblastic cells, and alkaline phosphates activity was low. These cells were differentiated after 12 days&#39; induction and showed an enhanced activity in alkaline phosphates.<br> <strong>Conclusion</strong>: The results showed that cord-blood mesenchymal stem cells could be a substitution source for bone-marrow mesenchymal stem cells and that they could be used in researches and clinical studies. &nbsp; Mesenchymal stem cells, Cord blood, Osteoblast, Differentiation 33 39 http://anatomyjournal.ir/browse.php?a_code=A-10-304-80&slc_lang=fa&sid=1 Masood Soleimani 10031947532846006855 10031947532846006855 Yes Hematology Department, Tarbiat Modarres University, Tehran, Iran. Saeed Kaviani 10031947532846006856 10031947532846006856 No Hosein Bahar Vand 10031947532846006857 10031947532846006857 No Amir Atashi 10031947532846006858 10031947532846006858 No