Anatomical Sciences Journal
مجله علوم تشریح
ASJ
Basic Sciences
http://anatomyjournal.ir
1
admin
17286158
17286158
en
jalali
1395
5
1
gregorian
2016
8
1
13
2
online
1
fulltext
en
Embryonic Stem Cell and Osteogenic Differentiation
Review
Review
<p style="text-align: justify;">Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs), and dental pulp stem cells (DPSCs) have received extensive attention in the field of bone tissue engineering due to their distinct biological capability to differentiate into osteogenic lineages. Application of these stem cells to bone tissue engineering requires their in vitro differentiation into bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This protocol would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to bone tissue engineering therapies. This review article critically examines the various experimental strategies used to direct the differentiation of ESC, BMMSC, UCB-MSC, ADSC, MDSC, and DPSC towards osteogenic lineages and their potential applications in tissue engineering, particularly in the regeneration of bone.</p>
Embryonic stem cell, Bone tissue, Osteogenesis, Tissue engineering
79
84
http://anatomyjournal.ir/browse.php?a_code=A-10-122-2&slc_lang=en&sid=1
Reza
Samanipour
samanipour.med@gmail.com
10031947532846003502
10031947532846003502
Yes
Department of Nuclear Engineering, Faculty of Basic Science and Nuclear Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Hossein
Salehi Rozveh
10031947532846003503
10031947532846003503
No
Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.