Volume 8, Issue 31 (Summer 2010)                   ASJ 2010, 8(31): 85-94 | Back to browse issues page

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Kaka G R, Sadraei S H, Mirshafiei G A, Saberi M, Jafari M. Study of the Effects of Hexamethylentetramine on Decrease of Defects of the Lung Tissue in the Rat Exposed to Sulfur Mustard. ASJ 2010; 8 (31) :85-94
URL: http://anatomyjournal.ir/article-1-517-en.html
Study of the Effects of Hexamethylentetramine on Decrease of Defects of the Lung Tissue in the Rat Exposed to Sulfur Mustard
Gholam Reza Kaka , Seyyed Homayoun Sadraei 1, Gholam Ali Mirshafiei , Mahdi Saberi , Mahvash Jafari
Abstract:   (865 Views)
Purpose: The aim of this study was to evaluate the effects of HMT on protection of lung tissue exposed to HD in the rat. Materials and Methods: In this study twenty Albino Wister adult male rats weighting 200±20 gram were used. Rats divided randomly into 4 groups (each group has 5 rats) as below: Normal saline group (NS), HMT group, HD group (0.25% HD) and HD+HMT group. Normal saline and HD solution were injected by intra tracheal catather. Animals in HMT and HD+HMT groups received HMT by intra peritoneal injection for 14 days daily. All rats were killed after 14 days, a part of lung tissue were removed, fixed and processed for histological evaluation by H&E staining and and apoptotic cell death study by TUNEL kit. In addition, biochemical study (catalase enzyme) was measured in all groups. Results: Histological examination and cell counting data revealed that there were no significant differences between Saline & HMT groups. Alveolar hemorrhage and inflammation, as well as, the number of apoptotic cells in the HD group was significantly increased when compared to HD+HMT group. Conclusion: HMT have prophylactic & therapeutics effects in the lung tissue against HD.
Keywords: Sulfur Mustard, Lung Tissue, Hexamethylenetetramine
     
Type of Study: Original | Subject: Morphometry
Received: 2021/12/28 | Accepted: 2010/08/19 | Published: 2010/08/19
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