Volume 8, Issue 30 (Spring 2010)                   ASJ 2010, 8(30): 13-24 | Back to browse issues page

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Mirakhouri F, Zeynali B, Parvaneh Tafreshi A. Expression of Gsk-3β And β-Catenin Proteins in the PMSG Stimulated Rat Ovary. ASJ 2010; 8 (30) :13-24
URL: http://anatomyjournal.ir/article-1-502-en.html
Abstract:   (676 Views)
Purpose: The ovary is an example of a developing tissue in which developmental prosses occur throughout reproductive life. We investigate the expression of GSK-3β and β-catenin- Wnt pathway molecules- in the rat ovary during follicular development. Materials and Methods: To induce follicular growth and development, 23 days old immature female rats were injected with 10 IU of PMSG. Forty and forty-eight hours after stimulation with PMSG, the sera was collected for hormone assay, and the ovary were dissected and prepared for immunohistochemistry (IHC( and western blot(WB). Results: Our IHC and WB analysis showed that the expression of pGSK-3β and active β-catenin was increased in PMSG primed rats in compared to those of intact groups. However, the total GSK-3β and β-catenin proteins remain unchanged. Conclusion: The results indicate this idea that gonadotropin (PMSG), stabilized β-catenin in GSK-3β independent manner in the rat ovary during the follicular development.
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Type of Study: Original | Subject: Morphometry
Received: 2021/12/27 | Accepted: 2010/05/30 | Published: 2010/05/30

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