Abstract: (740 Views)
Purpose: Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury (SCI) has not yet been studied.Materials and Methods: Rats were randomly divided into three groups of 18 rats each as follows: sham group (laminectomy), control group (SCI) and experimental group (EGCG). Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment.Results: The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group.Conclusion: EGCG treatment decreased secondary spinal cord injury.
Type of Study:
Original |
Subject:
Morphometry Received: 2021/12/27 | Accepted: 2009/11/28 | Published: 2009/11/28