Volume 12, Issue 3 (Summer 2015)                   ASJ 2015, 12(3): 137-140 | Back to browse issues page

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Salehi I, Shahab Soleimani M, Pourjafar M, Ghasemi Moravej F, Soleimani Asl S. Vitamin C Can Alter Lead-Induced Passive Avoidance Learning Impairment in Rats. ASJ. 2015; 12 (3) :137-140
URL: http://anatomyjournal.ir/article-1-120-en.html
1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Physiology, School of Science, Hamedan Branch, Islamic Azad University, Hamedan, Iran.
3- Department of Molecular Medicine, School of Science, Hamedan University of Medical Sciences, Hamedan, Iran.
4- Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:   (6025 Views)

Introduction: Lead (Pb) is a neurotoxin that its different effects on the central nervous system are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced amnesia.
Methods: Male Wistar rats were divided into 4 groups: the control (saline), negative control (lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1 month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was tested 24 hours after training. 

Results: The results showed that lead causes impairment in acquisition and retrieval processes of passive avoidance learning and memory. However, vitamin C administration reinforced passive avoidance learning and memory. All results were significant (P<0.001).
Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial learning and memory.

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Type of Study: Original |
Received: 2015/02/16 | Accepted: 2015/05/2 | Published: 2015/08/1

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