fa Morphometry Morphometry Original Original <strong>Purpose:</strong>The regeneration of axon and myelin sheet after crush injury of peripheral nerves involves interaction of several <u>ty</u>pes of cells, including Schwann cells, monocyte, macroph<u>ag</u>e and fibroblast. Amon<u>g </u>them, haematogenous macrophages invading into the peripheral nervous systein play a major role in myelin uptake during Wallerian degeneration. <strong>Materials and Methods</strong>: In this study 35 C57/BL6 male mice 10 weeks old were used and classified in 7 groups of 5 mice. The localization of epidermal-type fatty acid binding protein (E-FABP) in the mature mouse sciatic nerve after crush injury was examined by immuno-light microscopy. <strong>Results</strong>: Numerous macrophages immunopositive for both anti-E-FABP and F4/80 a macrophage marker. were found in degeneration process of sciatic nerve. Macrophages contained phagosomes of various sizes and they were regarded as those actively involved in the phagocytosis of sciatic nerve debrise. <strong>Conclusion</strong>: The present detection of E-FABP immunopositivity selectively in invading macrophages su<u>gg</u>ests possible involvement of E-FABP and/or its fatty acids ligand in the process of peripheral nerve regeneration.&nbsp; Sciatic nerve, Regeneration, Macrophages, FABP 0 0 http://anatomyjournal.ir/browse.php?a_code=A-10-304-247&slc_lang=fa&sid=1 Zahra Jamalpoor 10031947532846005929 10031947532846005929 No Mohammad Reza Nourani 10031947532846005930 10031947532846005930 Yes Hamid Reza Taghipour 10031947532846005931 10031947532846005931 No Youji Owada 10031947532846005932 10031947532846005932 No