Anatomical Sciences Journal
مجله علوم تشریح
ASJ
Basic Sciences
http://anatomyjournal.ir
1
admin
17286158
17286158
en
jalali
1386
11
1
gregorian
2008
2
1
6
25
online
1
fulltext
fa
Localization of Epidermal-Type Fatty Acid Binding Protein (E-FABP) in Degeneration and Regeneration of Sciatic Nerve after Crush Injury in Mouse
Morphometry
Morphometry
Original
Original
<strong>Purpose:</strong>The regeneration of axon and myelin sheet after crush injury of peripheral nerves involves interaction of several <u>ty</u>pes of cells, including Schwann cells, monocyte, macroph<u>ag</u>e and fibroblast. Amon<u>g </u>them, haematogenous macrophages invading into the peripheral nervous systein play a major role in myelin uptake during Wallerian degeneration. <strong>Materials and Methods</strong>: In this study 35 C57/BL6 male mice 10 weeks old were used and classified in 7 groups of 5 mice. The localization of epidermal-type fatty acid binding protein (E-FABP) in the mature mouse sciatic nerve after crush injury was examined by immuno-light microscopy. <strong>Results</strong>: Numerous macrophages immunopositive for both anti-E-FABP and F4/80 a macrophage marker. were found in degeneration process of sciatic nerve. Macrophages contained phagosomes of various sizes and they were regarded as those actively involved in the phagocytosis of sciatic nerve debrise. <strong>Conclusion</strong>: The present detection of E-FABP immunopositivity selectively in invading macrophages su<u>gg</u>ests possible involvement of E-FABP and/or its fatty acids ligand in the process of peripheral nerve regeneration.
Sciatic nerve, Regeneration, Macrophages, FABP
0
0
http://anatomyjournal.ir/browse.php?a_code=A-10-304-247&slc_lang=fa&sid=1
Zahra
Jamalpoor
10031947532846005929
10031947532846005929
No
Mohammad Reza
Nourani
10031947532846005930
10031947532846005930
Yes
Hamid Reza
Taghipour
10031947532846005931
10031947532846005931
No
Youji
Owada
10031947532846005932
10031947532846005932
No