fa Morphometry Morphometry Original Original <strong>Purpose: </strong>In the present study the effect of BMP-6 was investigated on chondrogenesis of adiposederived stem cells. <strong>Materials and Methods</strong>: Mesenchymal stem cells derived from subcutaneous adipose tissue were cultured on alginate scaffold to induce chondrogenesis in experimental group, with chondrogenic medium having BMP-6 growth factor for 3 weeks. In control group medium without BMP-6 was applied. The harvested constructs were examined with immunohistochemical and RT-PCR methods for assessment of cartilage-specific characteristics. <strong>Results:</strong> The results of immunohistochemical method revealed the presence of typical cartilage extracellular matrix components such as type II collagen and aggrecan in constructs induced by BMP-6 growth factor on alginate scaffold. In addition evaluation of the results of RT-PCR analysis confirmed the expression of cartilage- specific genes, such as type II collagen and aggrecan, in the differentiated cells under the influence of growth factor BMP-6. <strong>Conclusion</strong>: It can be concluded that BMP-6 promotes chondrogenesis of ADSC in 3-D and adipose-derived stem cells could be used for cartilage tissue engineering. Adipose-Derived Stem Cells, Alginate, Bmp-6, Tissue Engineering, Chondrogenesis 0 0 http://anatomyjournal.ir/browse.php?a_code=A-10-304-207&slc_lang=fa&sid=1 Batool Hashemi Bani 10031947532846006081 10031947532846006081 No Shahnaz Razavi 10031947532846006082 10031947532846006082 Yes Ebrahim Esfandiari 10031947532846006083 10031947532846006083 No Saeid Karbasi 10031947532846006084 10031947532846006084 No Mohammad Mardani 10031947532846006085 10031947532846006085 No Fatemeh Nadali 10031947532846006086 10031947532846006086 No Farzaneh Sadeghi 10031947532846006087 10031947532846006087 No Fereshteh Haghighat 10031947532846006088 10031947532846006088 No Shaghayegh Haghjou 10031947532846006089 10031947532846006089 No Vahid Gouharian 10031947532846006090 10031947532846006090 No