fa Morphometry Morphometry Original Original <strong>Purpose</strong>: The motor control deficits exhibited with Parkinson&rsquo;s disease (PD) are particularly well documented for sequencing tasks. The purpose of this study was to evaluate the neuroprotective potential of trans-resveratrol administration in an experimental model of PD.<br> <strong>Materials and Methods</strong>: 1 week before (baseline) the surgery rats were tested with systemic apomorphine (0.5 mg/kg i.p.) to evaluate the behavioral effect of the nigrostriatal lesion (turning behavior). The number of full rotations performed by the animals was registered at 10-min intervals for 60 min starting 1 min after apomorphine injection. The same procedure was repeated after 14 days post lesioning by 6-OHDA in the left striatum. Rotational response was expressed as the number of net full (360&deg;) turns per hour. The number of contralateral rotations was counted as positive scores for apomorphine. Net number of rotations was defined as the positive scores minus the negative scores.<br> <strong>Results</strong>: There were no significant differences among the groups at baseline (before surgery). Statistical analysis of the total net number of rotations made over a 60-min period 2 weeks after the surgery showed that apomorphine caused a very significant contralateral turning in the rats of the L group (P<0.001) and induced less significant rotations in the L+RSV group (P<0.05) in comparison with the SH group. Moreover, the group L+RSV showed a significant reduction of rotations (P<0.001) when compared with the L group.<br> <strong>Conclusion</strong>: In conclusion, administration of trans-resveratrol effectively counteracted progressive degeneration of nigrostriatal neurons caused by intrastriatal injection of 6-OHDA, thus lending further support to the neuroprotective potential of the drug. Trans-resveratrol, 6-hydroxydopamine, Parkinson’s disease, Rat 0 0 http://anatomyjournal.ir/browse.php?a_code=A-10-304-171&slc_lang=fa&sid=1 Abolfazl Faghihi 10031947532846006459 10031947532846006459 No Mohammad Taghi Joghataei 10031947532846006460 10031947532846006460 No Shahram Darabi 10031947532846006461 10031947532846006461 Yes Anatomy Department, Medical Faculty, Iran University Of Medical Science,Tehran, Iran. Mahdi Mahdizadeh 10031947532846006462 10031947532846006462 No Mehrdad Roughani 10031947532846006463 10031947532846006463 No Mehrdad Bakhtiari 10031947532846006464 10031947532846006464 No