fa Morphometry Morphometry Original Original <strong>Purpose</strong>: The aim of this study was to assess the efficacy of D-Penicillamine in reducing lead induced morphometric changes in rat testis.<br> <strong>Materials and Methods</strong>: Male adult rats were exposed to 0.4% lead acetate in drinking water for 8 weeks. After this period, 6 rats sacrificed and testes were removed to evaluate the effects of lead intoxication. The remained lead exposed rats were divided into two groups: one group received distilled water and the other group received 25-35 mg/kg/day of oral D-p treatment for six weeks, after one week of recovery. Testis morphometric changes were studied in H&E stained sections.<br> <strong>Results</strong>: Width of germinal epithelium and number of sertoli cells were decreased after 8 weeks of lead intoxication (P<0.05). These parameters were still significantly lower than control group after both of recovery and treatment periods (P<0.05).<br> <strong>Conclusion</strong>: This study showed that subchronic oral lead intoxication induces some changes in adult testis which are not reversible even after D-P administration. Lead Toxicity, Testis, Recovery, D-penicillamine, Rat 203 211 http://anatomyjournal.ir/browse.php?a_code=A-10-304-114&slc_lang=fa&sid=1 Danial Roshan del 10031947532846006202 10031947532846006202 Yes Anatomy & Histology Department, Gorgan Medical Faculty, Gorgan, Iran. Margan Kalavi 10031947532846006203 10031947532846006203 No Soraya Ghaffari 10031947532846006204 10031947532846006204 No Mohammad Gharavi 10031947532846006205 10031947532846006205 No Gholam Reza Roshan Del 10031947532846006206 10031947532846006206 No Mohammad Jafar Gol Ali Poor 10031947532846006207 10031947532846006207 No