fa Morphometry Morphometry Original Original <strong>Introduction</strong>: Originally the word tobacco comes from coniform particle (Y) or a pipe named tobago or tobacco that was used by mexican Indians for inhaling powdered leaves of a plant. Tobacco is addictive and it&#39;s consumption hurts the body in different ways. Tobacco have thousands of poisonous chemical compound such as Alkaloid, Nicotin, Nitrociamin and polycyclic aromatic hydrocarbons and also ten other Carcinogenic f substances. To study teratogenic effects of Nicotin in the development of Cartilages and bone formation in developing embryos.<br> <strong>Materials & Methods</strong>: 50 pregnant Balb/c mice were divided into experimental and control groups. 100 mg/kg nicotin was injected interaperetonealy early on day 10 of gestation. Control group received equal amount of sterile normal saline. All specimens were prepared for histological procedure and stained with alizarin red S. and alcian blue at pH 2.5 using peters&#39;s Method.<br> <strong>Results</strong>: We observed severe reduction in body weight, deleterious development of ossification center and cartilage formation in all experimental new born animals. There was no spontaneous defects among controls.<br> <strong>Conclution</strong>: Based on this study nicotin might interfas with normal development of cartilaginous as well as osseins tissues. Nicotin, Tobacco, Assification center, Teratogens, Cartilage 25 33 http://anatomyjournal.ir/browse.php?a_code=A-10-304-11&slc_lang=fa&sid=1 Hassan Farahi Shalchi 10031947532846006923 10031947532846006923 Yes Anatomy Department, Mashhad University, Mashhad, Iran. Ali Reza Fazel 10031947532846006924 10031947532846006924 No Ghasem Sazegar 10031947532846006925 10031947532846006925 No