en Neuroanatomy Neuroanatomy Original Original <div style="text-align: justify;"><strong>Introduction:</strong> Oxidative stress plays a key role in the pathophysiology of the Alzheimer&#39;s disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid &beta; (A&beta;)-induced neurogenesis deficits in rats.<br> <strong>Methods:</strong> Adult Wistar male rats in the current study were treated with intrahippocampal A&beta; as well as intraperitoneal callistephin injection. The day after the last administration, neuroD expression was assessed using an immunohistochemistry method. Finally, data were analyzed with SPSS using the one-way ANOVA test.<br> <strong>Results:</strong> Results of the current study showed that A&beta; significantly decreased the expression of neuroD and callistephin could attenuate these changes.&nbsp;<br> <strong>Conclusion:</strong> In conclusion, results of the study suggested that callistephin can improve A&beta;-induced neurogenesis changes in rats.</div> Alzheimer's disease, Neurogenesis, Anthocyanins 73 78 http://anatomyjournal.ir/browse.php?a_code=A-10-112-3&slc_lang=en&sid=1 Fahimeh Ghasemi Moravej f.ghasemimoravej@gmail.com 10031947532846003586 10031947532846003586 No Students Research Center, Hamedan University of Medical Sciences, Hamedan, Iran. Siamak Shahidi siamakshahidi@yahoo.com 10031947532846003587 10031947532846003587 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Mehdi Mehidzadeh maranaoo2004@yahoo.com 10031947532846003588 10031947532846003588 No Cellular and Molecular Research Center, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 10031947532846003589 10031947532846003589 Yes Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.