en Editorial Editorial <p dir="ltr" style="text-align: justify;">Hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited&nbsp;regenerative ability. After some serious injuries of the cartilage, healing process will take place&nbsp;through the formation of fibrocartilage structures. Currently, tissue engineering and cell therapy&nbsp;are 2 interesting therapeutic fields dealing with regenerative medicine. In this regard, tissue&nbsp;regeneration has found mesenchymal stem cells (MSCs) with self-renewal and multipotential&nbsp;abilities as the best candidates for this process. Growth and differentiation of MSCs are induced&nbsp;by growth factors. The purpose of this review article is to evaluate the effect of growth factors&nbsp;and their signaling pathways involved in differentiation of mesenchymal stem cells into&nbsp;chondrocytes in vitro conditions.</p> Mesenchymal stem cell, Growth factor, Chondro cartilage, Tissue engineering 183 190 http://anatomyjournal.ir/browse.php?a_code=A-10-116-1&slc_lang=en&sid=1 Babak Pourmollaabbassi ms.bpabasi@yahoo.com 10031947532846001332 10031947532846001332 No Department of Tissue Engineering, School of Basic Engineering, Islamic Azad University of Najafabad, Isfahan, Iran. Batool Hashemibeni hashemibeni@med.mui.ac.ir 10031947532846001333 10031947532846001333 Yes Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Ebrahim Esfandiari hashemibeni@med.mui.ac.ir 10031947532846001334 10031947532846001334 No Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.