en Original Original <p dir="ltr" style="text-align: justify;"><strong>Introduction:</strong> Lead (Pb) is a neurotoxin that its different effects on the central nervous system&nbsp;are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced&nbsp;amnesia.<br> <strong>Methods:</strong> Male Wistar rats were divided into 4 groups: the control (saline), negative control&nbsp;(lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To&nbsp;induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1&nbsp;month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was&nbsp;tested 24 hours after training.&nbsp;</p> <p dir="ltr" style="text-align: justify;"><strong>Results: </strong>The results showed that lead causes impairment in acquisition and retrieval processes&nbsp;of passive avoidance learning and memory. However, vitamin C administration reinforced&nbsp;passive avoidance learning and memory. All results were significant (P<0.001).<br> <strong>Conclusion:</strong> Vitamin C administration in rats counteracts the negative effect of lead on spatial&nbsp;learning and memory.</p> Lead, Vitamin C, Passive avoidance learning, Rats. 137 140 http://anatomyjournal.ir/browse.php?a_code=A-10-112-1&slc_lang=en&sid=1 Iraj Salehi irsalehi@yahoo.com 10031947532846001171 10031947532846001171 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Maryam Shahab Soleimani shaaadi2002@yahoo.com 10031947532846001172 10031947532846001172 No Department of Physiology, School of Science, Hamedan Branch, Islamic Azad University, Hamedan, Iran. Mona Pourjafar SR_SOLEIMANI@YAHOO.COM 10031947532846001173 10031947532846001173 No Department of Molecular Medicine, School of Science, Hamedan University of Medical Sciences, Hamedan, Iran. Fahimeh Ghasemi Moravej fahimehghasemimoravej@gmail.com 10031947532846001174 10031947532846001174 No Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 10031947532846001175 10031947532846001175 Yes Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.