TY - JOUR T1 - Vitamin C Can Alter Lead-Induced Passive Avoidance Learning Impairment in Rats TT - JF - ASJ JO - ASJ VL - 12 IS - 3 UR - http://anatomyjournal.ir/article-1-120-en.html Y1 - 2015 SP - 137 EP - 140 KW - Lead KW - Vitamin C KW - Passive avoidance learning KW - Rats. N2 - Introduction: Lead (Pb) is a neurotoxin that its different effects on the central nervous system are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced amnesia. Methods: Male Wistar rats were divided into 4 groups: the control (saline), negative control (lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1 month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was tested 24 hours after training. Results: The results showed that lead causes impairment in acquisition and retrieval processes of passive avoidance learning and memory. However, vitamin C administration reinforced passive avoidance learning and memory. All results were significant (P<0.001). Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial learning and memory. M3 ER -