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Volume 1, Issue 1 (Winter 2003)
ASJ 2003, 1(1): 35-39 |
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Kermanian F, Joghataei M T, Mahdi Zadeh M. To Study Teratogenic Effect Of Peganum Harmala Plant On Skeletal System And Mice Embryo Growth Rate Using Alizarin Red. ASJ 2003; 1 (1) :35-39
URL: http://anatomyjournal.ir/article-1-315-en.html
URL: http://anatomyjournal.ir/article-1-315-en.html
1- Anatomy Department, Iran Medical Sciences University, Tehran, Iran.
Abstract: (847 Views)
Introduction: To study the side effect of peganum plant on pregnant mice such as abortion or growth retardation. Peganum Harmala is a native plant of Iran. This plant has been used not only for the treatment of asthma, parasitical and microbial diseases but also as an emmenagogue and abortifacient agent. Since P.H. has alkaloids such as Vasicine and Vasicinone which have uterotonic activity like Methergin and Oxytocine, in traditional medicine it has been used for abortion or postpartum hemorrhage.
Materials & Methods: In order we injected P.H. intraperitoneally to the pregnant mice in three doses: 6, 15, 30 mg/kg/day from the first up to the 10th day of pregnancy, then we killed the mice in 15-19th pregnancy days. After Laparatomy we extracted fetuses and measured their height and weight. Then the fetuses were stained with Alizarin Red and observed with stereomicroscope for skeletal anomalies.
Results: The Results showed that there were no skeletal anomalies. But in comparison with control group, absorption and decrease of height and weight was observed.
Conclusion: Since the most absorption of the fetuses was in the last days of pregnancy (18-19th), we believe that P.H. causes abortion by means of affecting on growth and development of fetus.
Materials & Methods: In order we injected P.H. intraperitoneally to the pregnant mice in three doses: 6, 15, 30 mg/kg/day from the first up to the 10th day of pregnancy, then we killed the mice in 15-19th pregnancy days. After Laparatomy we extracted fetuses and measured their height and weight. Then the fetuses were stained with Alizarin Red and observed with stereomicroscope for skeletal anomalies.
Results: The Results showed that there were no skeletal anomalies. But in comparison with control group, absorption and decrease of height and weight was observed.
Conclusion: Since the most absorption of the fetuses was in the last days of pregnancy (18-19th), we believe that P.H. causes abortion by means of affecting on growth and development of fetus.
Type of Study: Original |
Subject:
Morphometry
Received: 2021/12/25 | Accepted: 2003/02/21 | Published: 2003/02/21
Received: 2021/12/25 | Accepted: 2003/02/21 | Published: 2003/02/21
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