Combined Effect of Ginger and Pumpkin Seed Extracts on Rat Testis and Serum Biochemical Parameters after Cyclophosphamide Treatment

Mohamadi, Forouzan; Nikzad, Hossein; Taherian, Aliakbar; Taghizadeh, Mohsen; Azami-Tameh, Abolfazl; Naderian, Homayon; Atlasi, Mohammad Ali

Volume 11, Issue 1 (Winter 2014) ASJ 2014, 11(1): 33-40 | Back to browse issues page

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Mohamadi F, Nikzad H, Taherian A, Taghizadeh M, Azami-Tameh A, Naderian H et al . Combined Effect of Ginger and Pumpkin Seed Extracts on Rat Testis and Serum Biochemical Parameters after Cyclophosphamide Treatment. ASJ 2014; 11 (1) :33-40
URL: http://anatomyjournal.ir/article-1-69-en.html

Combined Effect of Ginger and Pumpkin Seed Extracts on Rat Testis and Serum Biochemical Parameters after Cyclophosphamide Treatment

Forouzan Mohamadi¹

, Hossein Nikzad

¹, Aliakbar Taherian¹

, Mohsen Taghizadeh¹

, Abolfazl Azami-Tameh¹

, Homayon Naderian¹

, Mohammad Ali Atlasi¹

1- Kashan University of Medical Sciences

Abstract: (6589 Views)

Introduction: Cyclophosphamide is a chemotherapy drug with several side effects on various organs such as male reproductive system that can cause infertility. In this study, we assessed combined effect of ginger and pumpkin extractson rat testis after CP injection.

Methods: Forty adult male rats were randomly divided into 4 groups: The control group received intraperitoneal injection of isotonic saline solution. The cyclophosphamide (CP) group received a single dose of cyclophosphamide (100 mg kg_1BW) intraperitoneally. Combined extracts (ginger+ pumpkin) group received orally 300 mg combined extracts and combined extracts(ginger+ pumpkin) +CP groups received orally 300 mg combined extracts for a period of 6 weeks after CP injection.

Results: Our results showed that although ginger extract could not change testis weight, testosterone, malondialdehyde (MDA) and ROS, antioxidant level in serum was increased significantly. Epithelium thickness and tube diameter were decreased in combined groups with or without CP in comparison to control group. The combined extract could improve histological changes in both combined extract and combined extract+ CP compared to CP group, which could be attributed to the higher serum level of antioxidants.

Conclusion: The administration of combined extracts

Keywords: Testis, Ginger, Pumpkin, Cyclophosphamide, Biochemical parameters

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Type of Study: Original |
Received: 2013/08/14 | Accepted: 2013/12/24 | Published: 2014/02/1

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